Introduction

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"The best laid plans of mice and men go oft astray." - Robert Burns

This saying so impressed John Steinbeck that he titled his novel after it. 

What does this saying mean to you?  As you read the novel, Of Mice and Men, try to determine the connection to this phrase.  What plans, dreams and wishes of the characters were made to go astray?  How does this lead to feelings of isolation and loneliness?